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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1936 2
1949 1
1953 1
1954 1
1956 1
1962 1
1964 1
1965 1
1966 2
1967 2
1968 3
1969 4
1970 3
1971 6
1972 7
1973 5
1974 10
1975 40
1976 52
1977 38
1978 34
1979 39
1980 36
1981 53
1982 33
1983 56
1984 57
1985 69
1986 78
1987 78
1988 81
1989 79
1990 96
1991 105
1992 104
1993 119
1994 116
1995 141
1996 156
1997 164
1998 174
1999 187
2000 242
2001 256
2002 266
2003 326
2004 397
2005 439
2006 454
2007 454
2008 454
2009 453
2010 518
2011 528
2012 524
2013 527
2014 536
2015 510
2016 489
2017 468
2018 464
2019 495
2020 502
2021 546
2022 547
2023 428
2024 136

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12,060 results

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Page 1
Key Peptides and Proteins in Alzheimer's Disease.
Penke B, Bogár F, Paragi G, Gera J, Fülöp L. Penke B, et al. Curr Protein Pept Sci. 2019;20(6):577-599. doi: 10.2174/1389203720666190103123434. Curr Protein Pept Sci. 2019. PMID: 30605056 Review.
Alzheimer's Disease (AD) is a form of progressive dementia involving cognitive impairment, loss of learning and memory. Different proteins (such as amyloid precursor protein (APP), beta- amyloid (Abeta) and tau protein) play a key role in the initiation and p …
Alzheimer's Disease (AD) is a form of progressive dementia involving cognitive impairment, loss of learning and memory. Different protein …
Structure of the hypothetical protein TTHA1873 from Thermus thermophilus.
Yuvaraj I, Chaudhary SK, Jeyakanthan J, Sekar K. Yuvaraj I, et al. Acta Crystallogr F Struct Biol Commun. 2022 Sep 1;78(Pt 9):338-346. doi: 10.1107/S2053230X22008457. Epub 2022 Aug 30. Acta Crystallogr F Struct Biol Commun. 2022. PMID: 36048084 Free PMC article.
A structural homology search indicates that the protein has moderate structural similarity to one domain of cell-surface proteins or agglutinin receptor proteins. Red blood cells showed visible agglutination at high concentrations of the hypothetical …
A structural homology search indicates that the protein has moderate structural similarity to one domain of cell-surface proteins …
Stabilization of proteins in solid form.
Cicerone MT, Pikal MJ, Qian KK. Cicerone MT, et al. Adv Drug Deliv Rev. 2015 Oct 1;93:14-24. doi: 10.1016/j.addr.2015.05.006. Epub 2015 May 14. Adv Drug Deliv Rev. 2015. PMID: 25982818 Free PMC article. Review.
Immunogenicity of aggregated or otherwise degraded protein delivered from depots or other biopharmaceutical products is an increasing concern, and the ability to deliver stable, active protein is of central importance. ...Each of these approaches is ultimately motiv …
Immunogenicity of aggregated or otherwise degraded protein delivered from depots or other biopharmaceutical products is an increasing …
Protein-Protein and Peptide-Protein Interactions of NudE-Like 1 (Ndel1): A Protein Involved in Schizophrenia.
Hayashi MA, Felicori LF, Fresqui MA, Yonamine CM. Hayashi MA, et al. Curr Protein Pept Sci. 2015;16(8):754-67. doi: 10.2174/1389203716666150505225251. Curr Protein Pept Sci. 2015. PMID: 25961396 Review.
It is still not clear if the protein-protein interaction between Ndel1 and DISC1 is enough to explain all cellular functions attributed to these proteins, but there are several lines of evidence suggesting the importance of the catalytic activity of Ndel1 for …
It is still not clear if the protein-protein interaction between Ndel1 and DISC1 is enough to explain all cellular functions a …
Functional characterization of a hypothetical protein (TTHA1873) from Thermus thermophilus.
Iyyappan Y, Dhayabaran V, Elayappan M, Chaudhary SK, Palaniappan C, Kanagaraj S. Iyyappan Y, et al. Proteins. 2023 Oct;91(10):1427-1436. doi: 10.1002/prot.26530. Epub 2023 May 31. Proteins. 2023. PMID: 37254593
T. thermophilus genome has ~2218 genes, out of which 66% (1482 genes) have been annotated, and the remaining 34% (736 genes) are assigned as hypothetical proteins. In this work, biochemical and biophysical experiments were performed to characterize the hypothetic …
T. thermophilus genome has ~2218 genes, out of which 66% (1482 genes) have been annotated, and the remaining 34% (736 genes) are assigned as …
Cold comfort pharm.
Fleetwood-Walker SM, Proudfoot CW, Garry EM, Allchorne A, Vinuela-Fernandez I, Mitchell R. Fleetwood-Walker SM, et al. Trends Pharmacol Sci. 2007 Dec;28(12):621-8. doi: 10.1016/j.tips.2007.10.007. Epub 2007 Nov 9. Trends Pharmacol Sci. 2007. PMID: 17996956 Free article. Review.
This review focuses on the role of one of these, TRPM8, which has been implicated in cool sensation and cold pain by recent knockout mouse studies, but remarkably also appears capable of eliciting a novel analgesic gating control over noxious inputs in chronic pain states. We dis …
This review focuses on the role of one of these, TRPM8, which has been implicated in cool sensation and cold pain by recent knockout mouse s …
PML Body Biogenesis: A Delicate Balance of Interactions.
Silonov SA, Smirnov EY, Kuznetsova IM, Turoverov KK, Fonin AV. Silonov SA, et al. Int J Mol Sci. 2023 Nov 24;24(23):16702. doi: 10.3390/ijms242316702. Int J Mol Sci. 2023. PMID: 38069029 Free PMC article. Review.
One of the general structural proteins of PML bodies is a member of the tripartite motif (TRIM) family-promyelocytic leukemia protein (PML). ...Additionally, based on the available literature, we propose a new hypothetical model of PML body formation....
One of the general structural proteins of PML bodies is a member of the tripartite motif (TRIM) family-promyelocytic leukemia prot …
Interpretation of Hydrogen/Deuterium Exchange Mass Spectrometry.
Hamuro Y. Hamuro Y. J Am Soc Mass Spectrom. 2024 May 1;35(5):819-828. doi: 10.1021/jasms.4c00044. Epub 2024 Apr 19. J Am Soc Mass Spectrom. 2024. PMID: 38639434 Review.
Whereas the free energy change upon mutation can be directly measured by the HDX rates, the free energy change upon ligand binding may be complicated due to the presence of unbound analyte protein in the protein-ligand mixture. Third, the meanings of HDX and other b …
Whereas the free energy change upon mutation can be directly measured by the HDX rates, the free energy change upon ligand binding may be co …
Amyloid-type Protein Aggregation and Prion-like Properties of Amyloids.
Willbold D, Strodel B, Schröder GF, Hoyer W, Heise H. Willbold D, et al. Chem Rev. 2021 Jul 14;121(13):8285-8307. doi: 10.1021/acs.chemrev.1c00196. Epub 2021 Jun 17. Chem Rev. 2021. PMID: 34137605 Free article. Review.
This review will focus on the process of amyloid-type protein aggregation. Amyloid fibrils are an important hallmark of protein misfolding diseases and therefore have been investigated for decades. ...The review starts with a summary of what is known and speculated …
This review will focus on the process of amyloid-type protein aggregation. Amyloid fibrils are an important hallmark of protein …
Pathways to chromothripsis.
Ivkov R, Bunz F. Ivkov R, et al. Cell Cycle. 2015;14(18):2886-90. doi: 10.1080/15384101.2015.1068483. Epub 2015 Jul 15. Cell Cycle. 2015. PMID: 26178348 Free PMC article.
Recent studies have illuminated mechanistic links between these 2 signaling pathways, including a novel PTCH1 homolog that is regulated by p53. Here, we integrate this new pathway into a hypothetical model for the catastrophic DNA breakage that appears to trigger profound …
Recent studies have illuminated mechanistic links between these 2 signaling pathways, including a novel PTCH1 homolog that is regulated by p …
12,060 results
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